There are three game modes available in Family Guy Back to the Multiverse:

Story Mode
This mode can be played as either Solo or Co-op and has a drop-in and out system that is easy to use. Each level has a theme and ends with a boss.

There are several challenges included in the game. Depending on the challenge, players can select difficulty, race against the clock or play against a friend.

There are four modes available in multiplayer: Deathmatch, Multiverse Madness, Capture the Greased-Up Deaf Guy and INFILTRATION!